Related Clues:

• Require bed rest, perhaps
• Sneeze, cough, etc.
• Have 35-Down
• Not feel oneself
• Take to one's bed
• Affect adversely
• Cause to suffer
• Feel off
• Feel feverish
• Feel out of sorts
• Bother greatly
• 'ard rain?
• Be bedbound
• Have 43-Across, maybe
• Cause trouble to