Related Clues:

• Trouble greatly
• Wear on one's conscience
• Bother big-time
• ___ Joe's
• "___ Joe's" (sandwich board message)
• Continuously bother
• Make anxious
• Really rankle
• Words on a sandwich board
• Give business to, as a café
• Annoy a lot
• Vex supremely
• "___ Joe's" (restaurant sign)
• Trouble big-time
• Patronize, as a bistro