Related Clues:

• Neuralgia
• Tough row to hoe
• Major annoyance
• Prerequisite for gain?
• No gain without it
• Aspirin target
• Suffering partner
• Arduous chore
• Difficult challenge
• Irksome sort
• Charley horse, e.g.
• Percocet's target
• Tough test
• What an analgesic stops
• It can follow a fall