Related Clues:

• Inner turmoil
• Sad state
• Source of despondency
• Wednesday's Child is full of it
• It's hard to bear
• Bad tidings
• Reason to cry 'Alas!'
• Cry of grief
• Cause of grief
• Deep sorrow
• Grievous distress
• ''__ is me!''
• Tragedy
• "___ is me!"
• Cause of trouble