Related Clues:

• "This is unbearable!"
• 'It's just too much for me'
• Negative response to an invite
• "All booked up, sorry"
• "It's too hard for me!"
• "It's too hard for me"
• Japanese drama opened first half in despair
• 'Sorry, it's impossible for me'
• Zero chance of a good result
• "That is just TOO much for me!"
• Busy person's response to an invitation
• "Sorry, too busy" (In this clue's answer, note the last 3 letters + the first 3 of 21-Across)
• "Today's a no-go for me"
• "It's all too much"
• "That's not possible for me"