Related Clues:

• Rile
• Stick in one's craw
• Ruffle one's feathers
• Bother continually
• Grate on
• Get one's dander up
• Annoy greatly
• Anger, with 'up'
• Evoke bitterness
• Antagonize
• "___ Joe's"
• Having the toilet paper roll put on the 'wrong' way, e.g.
• Bug big-time
• Needle, perhaps
• Pet problem?