Related Clues:
- Pennsylvania's fourth-largest city
- Large lake named after a tribe
- Eastern city on I-90
- Canal of Rome
- Home of Gannon University
- Fort ___, captured by U.S. forces in 1814
- Old Ohio/New York tribe
- Detroit River outlet
- Ontario lake
- Erie-to-Ontario river
- Seneca foe
- Lake ___, outlet of the Maumee River
- Pennsylvania's Flagship City
- Border river
- Mercyhurst College city