Related Clues:

• Professor Moriarty, for one
• Villainous scientist character, say
• Lex Luthor, for example
• Enemy who's difficult to outsmart
• Typical Bond foe
• One who might cackle 'Mwa-ha-ha-ha!'
• Mad scientist, maybe
• Villainous scientist character, maybe
• Supersmart supervillain
• Villain who's both admired and feared