Related Clues:

• Bugs big-time
• Ruffles the feathers of
• Puts out of sorts
• Tries the patience of
• Is bothersome to
• Succeeds in annoying
• Bothers big-time
• Wears on
• Annoys big-time
• Annoys to no end
• Grinds one's gears
• Rankles runner taking in run around ...