Related Clues:

• Tyrant captures northern retreat — it's hopeless
• To not aspire so much is futile
• Wretched name for Slough medical specialty
• Almost without hope
• Discouraged dip (not cold) in water feature? The opposite!
• Having no reason to expect a good outcome
• With no reason to expect success
• Awful trampoline finally put in without springs?
• Wretched depression's solved firstly taking exercise
• Hardly promising
• Certain not to succeed
• Downhearted university teacher conceals especially brief depression
• Having no chance of success
• Irremediable
• Incompetent, very bad