Related Clues:

• Chafe
• Bother the heck out of
• Gnaw at
• Really ruffle
• Really bug
• Really get to
• Make upset
• Get on one's nerves
• Piss off
• Raise one's hackles
• Try the patience of
• Get on the bad side of
• Be a thorn in the side of
• Bother greatly
• Bug the hell out of