Related Clues:

• Nuisance, so to speak
• "No ___, no gain"
• What an analgesic treats
• Heartbreak at introductions to protected areas in Nepal
• Physical suffering
• Leader of side dropped by country is hurt
• Physical hurt
• Hurt feeling
• It comes with the gain game!
• It is often gained
• Mental distress
• Suffering, distress
• It often comes with sporting gain
• A bit of glass in one's ear can cause discomfort
• Annoying person with French bread