Related Clues:

• Taxman getting it in angry tirade is a nuisance
• I rave about educated girl ignoring a pest
• Institute writing with bluster over city centre will only inflame things
• Smoke in one's eyes, say
• Grain of sand, to a pearl oyster
• Woman educated in Irish books causes trouble
• Irish girl joins National Trust — a cause of annoyance
• Cause of itch
• It's annoying
• Inflammation-causing substance such as pollen
• Two of the Kings of Ireland, one upset by heartless taunt that's a thorn in someone's side
• Salt on an open wound, for example
• Goes off to airport terminal and leaves Palermo - how maddening!
• Irish girl meeting conservationists, a thorn in the flesh
• Pesky annoyance