Related Clues:

• It's hard to bear
• Cause for weeping
• Bad tidings
• Reason to cry 'Alas!'
• Cry of grief
• "Life sucks!"
• Cause of grief
• Deep sorrow
• Grievous distress
• ''__ is me!''
• Tragedy
• "___ is me!"
• Cause of trouble
• With 51-Down, cry of sorrow
• Melodramatic lament