Related Clues:

• Gossip about retired medic? Forget it!
• Notwithstanding journalist's rising malice
• Just as shiny as before, but that's all right
• Notwithstanding, tips back into the river
• Notwithstanding, dumps back in the river
• What is there in a vacuum? Never mind!
• New team not beginning to react? It makes no difference
• Gas, including oxygen, beginning to materialise? It's not important
• In defiance of
• Undeterred by neck of land in river
• It makes no difference
• Feature of vacuum that's unimportant
• 'Don't sweat it!'
• Definition of a vacuum?
• 'Let's not worry about it'