Related Clues:
- Extremely intense training in river's heading for trouble
- River disease is most serious
- Most discerning river bug
- Profoundest
- Look towards the setting sun, being most depressed
- Least shallow river -- nuisance going under
- Most intense river disease
- Least (in number)
- River vermin furthest down
- Flower with blight -- that's most serious
- Most scurrilous
- Extremely poor setters no longer possessed pens
- Most low
- Most mysterious bug seen by river
- "The First Cut is" this?