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Related Clues:
- Up against it, one having damaged pancreas
- Facing a problem
- Facing difficulties in moving to Spain
- Having major difficulty
- With one's back against the wall
- ... having some spa treatment for it?
- Needing to be bailed out ... or where 20-, 27-, 45- and 51-Across may be found
- Having trouble with sugary plums and raspberries, for instances
- Up against it
- Sounds like Brian is here having difficulties
- Experiencing trouble
- Up against it flying to Spain
- Changing to spin restricts amateur's start on a sticky wicket
- Facing serious trouble
- Needing assistance, maybe