Related Clues:

• Orkin target
• 43-Down, e.g.
• Vexation
• Dennis, to Mr. Wilson
• Annoying sort
• Raid target
• Annoying insect
• Arborist's concern
• Fly, e.g.
• Annoying person
• Little brother, often
• Royal pain
• Irritant
• Unwanted visitor
• Ant, maybe