Related Clues:

• How come?
• Question of puzzlement from character becoming audible
• Word often seen near 42-Down
• Word that sounds like its last letter
• Another of the five W's
• Philosophical question
• "Seriously?"
• Question raised by four squares in this puzzle?
• ''How come?''
• Who, what, when, where and ___
• 'HOW COULD THIS HAPPEN?!'
• "___ Can't We Be Friends?"
• 'Who's on First?' left fielder
• Question pronounced like its last letter
• Tot's query