Related Clues:

• Trouble greatly
• Wear on one's conscience
• Bother big-time
• ___ Joe's
• "___ Joe's" (sandwich board message)
• Continuously bother
• Patronize, in a way
• Make anxious
• Really rankle
• Words on a sandwich board
• Annoy a lot
• Vex supremely
• "___ Joe's" (restaurant sign)
• Patronize, as a bistro
• Irritate big-time