Related Clues:

• Callous
• Cruel and unfeeling
• Ulcer (anag)
• Rough and cruel
• Mean, and then some
• Awful dead end in the lab up there
• Really, really tough
• Steve Martin's '___ Shoes'
• Very unkind
• Aftershave contracts boxer that's tough
• Severe, as weather
• Not nice at all
• Senselessly cruel
• A bit worse than 44-Across
• Heartbreaking for the French to come back in the end to type of French vineyard