Related Clues:
- Aphid, to a fruit tree
- Dennis the Menace, to Mr. Wilson
- Mosquito or mole, e.g.
- Fly, perhaps
- 17-Across in the neck
- Annoying bug
- Irksome one
- Pain in the ass
- One who 26-Across
- Destructive insect or nuisance
- A nuisance - step on it
- Troublesome man or animal
- Pest, source of annoyance
- Pest or irritation
- Annoying person or thing