Related Clues:

• Grate on
• Get one's dander up
• Annoy greatly
• Anger, with 'up'
• Antagonize
• Bug big-time
• Boil one's blood
• Really annoy
• Bring exasperation
• Chafe
• Bother the heck out of
• Gnaw at
• Make hot
• Incite anger in
• Really ruffle