Possible Clues:

• First word of a rhyming phrase meaning very close family and friends
• In tree house, are becoming most familiar?
• Like Proxima Centauri, of all stars but the sun
• Most close by are in eyrie?
• Are in retreat, like one's neighbours?
• Eastern (anag) — resembling most closely
• Most mean, accommodating some seeds, to fit in another
• Dearest partner?
• Like the exit one should leave through in a fire drill
• Family locates half of stores in well-kept surroundings