Possible Clues:

• Eye sore?
• Filthy place at end of promenade, an eyesore
• Irritating subject for an ophthalmologist?
• Sebaceous gland issue
• It may be involved in nasty eye
• Ophthalmological woe
• Observer's complaint of filthy place, say
• Filthy place reported -- a problem with infection
• Remain without a leader in enemy uprising?
• Extraocular annoyance