Possible Clues:

• Inflammation on the eye
• Some nasty eye inflammation?
• Broadcast set to receive unknown viewer's complaint
• Design lacking formal finish is painful on the eye
• Ophthalmologists call it a hordeolum
• Somewhere not very clean reported in complaint
• Observer's problem, subeditor tampering with yesterday's editorial, all kicking off
• Possible reason to forgo mascara
• Complaint made using pen name at the end
• Infection causing some misty eyesight?