Possible Clues:

• 121 Across woe
• Eye problem, small, yet to be cured
• Concern for an ophthalmologist
• Inflammation coming in worst yet
• Saint with the old eye problem
• Designer's concern - without top labels this is an eyesore
• Ocular lid woe
• Hasty examination reveals inflammation of a gland
• Ocular bump
• Eyesore some tomfool Yankee erected first of all