Possible Clues:

• Huge, in slang
• Columbus' world
• "___ Cane" (1962 movie)
• Huge, so to speak*
• Extremely, in 1970s slang
• ''___ Cane'' (1962 film)
• Paganini's world
• Columbus's world
• "___ Cane" (1963 movie)
• Galileo's world