Possible Clues:

• Migraine, for one
• Major problem
• Big bother
• Problem for the man, an American lawyer and revolutionary
• Laugh about woman getting cold -- and what comes with it?
• Two men set about a retired bounder over being such a pain
• Problem caused by leader, a revolutionary
• On top of it all, he, a father, gets Guevera sore
• Worry, trouble (colloq.)
• Severe problem