Possible Clues:

• The end of my cane is lost in spirit
• Esoteric
• Of hidden or symbolic meaning as in religion
• Could one's contemplation remove the end of my cane like this?
• It sounds as if 24 across might stick at being so spiritual as this
• Home of the sloop Estella A
• A spiritual young lady called Tick, by the sound of it
• Like Teresa - chemistry isn't the same without her
• It's beyond comprehension how that cane of mine has lost its end
• 'Heavens, it's turning cold', declares seer