Possible Clues:

• Make someone feel upset and disturbed
• Seen in drink, swimmer in distress
• Have a drink containing fish for a change
• Radical reorganisation at university following earth tremor
• Fundamental change
• Shape UK could develop from this?
• Mix a cocktail, say, and get fish in to eat
• Disturbance: reorganisation
• Fish in drink causes upset
• Have evening meal traditionally including fish for a change