Possible Clues:

• "...depressed, or is ___ mess?" (lyrics to They Might Be Giants' "Particle Man")
• '...or is ___ speck?' (They Might Be Giants line)
• "Isn't __ riot?!": "Funny guy!"
• 'Is ___ keeper?' (relationship quiz)
• '... from man, made -- woman': Genesis 2:22
• "Isn't __ bit like you and me?": "Nowhere Man" lyric
• Jimmy Buffett's 'Ain't -- Genius'
• 'Isn't bit like you and me?'
• 'Wasn't ___ most peculiar man?' (Simon & Garfunkel lyric)
• 'Isn't — little old for her?'