Possible Clues:

• ___ May, surrogate mother for Spider-Man
• Relative not beginning to brag
• She has you relatively surrounded by the one in the hill
• The start of 25 across is thus relatively around you
• Bee, for one
• Possible babysitter
• Great-___
• Charley's in play?
• Patty or Selma, to Bart Simpson
• P. G. Wodehouse's ___ Agatha