Possible Clues:

• Reportedly, where injection goes will be making no difference
• Unsuccessfully leading army maybe around island
• 'To no avail (2,4)'
• Fruitlessly drugs may circulate here, we hear
• Virginia caught between two entrances without result
• At the front, protecting one, to no avail
• Reportedly where to get blood for nothing
• Where one may have injection, say, to no purpose
• Popular humour by the sound of it with no purpose
• Without success or a result