Possible Clues:

• Hopin' to find a way to cure the pain
• Wrong way to rest in peace in a sin. This will help the pain of it
• Hoping for reduction in medicine
• Having high hopes without good drug
• It makes you a better person
• Spin with the air for the pain
• Begin 29 across in the end in pain
• Might this be a pair with sin for pain?
• Champion in bed with small cigars
• Ibuprofen alternative / One with ambitions? (Hint: Note letters 4 and 6)