Possible Clues:

• Meditate about nothing that works with a computer
• Vermin in doctor's practice
• Minnie, for one
• Creature in middle of foaming river at York
• Nuisance in one's house, help on one's screen
• Keep the pest in hand if you use your computer
• See 1 Down
• Main character from "The Tale of Despereaux," e.g
• Computer accessory has second function
• Small rodent — computer attachment