Possible Clues:

• 'Disease' of abundance
• Ennui + wealth = ___
• Psychological malaise supposedly affecting the rich
• Material complaint following infection deaths reported among drivers
• Malaise characterised by feelings of guilt and isolation
• Anti-consumerist portmanteau popularized in a 2001 best-seller
• Woe that's the result of extreme materialism
• 'Illness' affecting the wealthy