Possible Clues:

• Declaration of Independence's first word
• Question of the day?
• First word of the Declaration of Independence
• At what point
• At what point does it stop alcohol delivery?
• "___ Harry Met Sally . . ."
• 'Since --?!'
• A question of time 42. Neither 20-Down nor 26-Down
• Question not asked in this puzzle's theme words
• Who, what, why, how and ___