Possible Clues:

• Brother in a video game franchise
• Italian bear touring island by India
• Italian form of Lewis
• Character who can be played in every installment of 26-Down
• Lover of Giorgetta in Puccini's 'Il Tabarro'
• Mario’s brother
• Video game character with an 'L' on his hat
• Mario's brother, in gaming
• Mario’s brother in video games
• First of all, looking up, is greeting Italian — this one?