Possible Clues:

• Manhattan area
• Section of NYC, with 'The'
• Seedy Manhattan area
• The --, street in New York noted for its cheap hotels and bars
• Stereotypical bum's place
• Seedy section of N.Y.C.
• Big Apple area (with "the")
• Derelicts' domain
• Shady American low-lifes hang out here
• The ___ Boys ('40s-'50s film group)