Possible Clues:

• NYC area, with 'the'
• The --, a street in Manhattan, an archetypal skid row
• The --, street in New York noted for its cheap hotels and bars
• Little Italy neighbor
• Manhattan area, with "the"
• Once-seedy section of NYC
• Once-seedy section of Manhattan
• Big Apple area, with 'the'
• Big Apple area, with "the"
• The ___ Boys (40's-50's film group)