Possible Clues:

• Lacking, to Louis
• ___ doute (certainly)
• Without (literary)
• French word whose opposite is 2-Down
• Without places to recuperate
• ___ serif typeface
• Word repeated four times in the last line of Shakespeare's 'All the world's a stage' speech
• With 27-Down, like some letters
• With 49-Down, a type style
• Without, to the chic