Possible Clues:

• Big toe woe, often
• 'The disease of kings'
• "The disease of kings"
• Affliction causing severe joint pain
• Cause of joint pain
• Hole in belly causes disease
• Painful affliction in end of leg revealed
• Nothing in belly causes disease
• Realised, as we did, Brexit not to Macron's taste?
• Big toe affliction, often