Possible Clues:

• Tube weapon shifted below to smother radio signal
• Drug that is, ironically, inhaled
• Crushing setback
• 2001 crime film starring Johnny Depp as a cocaine smuggler
• Stupidly lose
• Fan of Wales at first supports Bale with love
• Explode, with 'up'
• White lines, slangily
• Serious punch
• Word with smoke or kisses